Dr Tianyu Zhang  is the director of theTuberculosis Research Laboratory of the State Key Laboratory of Respiratory Disease (SKLRD) and the leader of thePathogenic Bacteria ResearchLaboratory. At the same time, Dr Zhang is also a professor and doctoral supervisor of University of Chinese Academy of Sciences (UCAS), University of Science Technology of China (USTC) and Anhui University. His team has been focusing on mycobacterial diseases, including  infectious disease tuberculosis (TB) , especially anti-TB drug discovery and development,mechanisms of action of drugs and new compounds, novel diagnosis for the past 15 years. To date, his team has achieved fruitful results in screening, evaluating models and evaluating the efficacy of anti-TB drugs/regimens, some of which are at an advanced level of development. One drug candidate codeveloped by his team has transferred to a pharmaceutical company and the recent results have shown it is very promising not only for treating TB.Most importantly, his team has achieved breakthrough discoveries in the areas of TB diagnosis and the resulting novel drug sensitivity testing. Not only has histeam carried out genetic manipulation of Mycobacterium tuberculosis (M. tuberculosis)with significant results but they have also studied the mechanism(s) of resistance involved in a number of anti-TB drugs. Additionally, their research on the development of TB therapeutic vaccine has achieved promising initial results.

Current research of Dr Zhang’s lab is mainly focusing on the research and development antimycobacterial drugs, studying the mechanism(s) of action andresistance of various anti-TB drugs and the new drug activecompounds and developmentof a novel diagnostic tool invented by his lab. Inaddition, his research is also involved in the postgenomics of mycobacteria, immunologyand development of vaccine(s) against TB as well as drugs against other pathogenic bacteria (such as Helicobacter pylori, Klebsiella pneumoniae, etc) and their mechanisms of action.

Dr Zhang’s lab is currently in partnership with several international institutes such as the Commonwealth of AustraliaOrganization for Scientific and Industrial Research, Johns HopkinsUniversity and NewYork University, etc. It is therefore not surprising that every year his lab attract students from all over the world. To date,three international doctoral students (Julius Ndirangu Mugweru and Njire MosesMucugi) and six native masters have graduated from his lab. Dr Zhang is currently supervising one international postdoctoral fellow (Shahzad Akbar Khan), seven international PhD students (Neamul Kabir Zihad,Abdallah E. Ahmed,Bate Ndip Petuel Ndip,Hafiz Muhammad Adnan Hameed, Chiranjibi Chhotaray, Md Mahmudul Islam andChiwala Gift),two native doctoral students, five international master students(Md. Shah Alam, Buhari Yusuf, Saraswati Poudel,SanjeepApkota and Zafran Khan) ,as well as nine native master students.

1.1995-1999: Capital Normal University, Beijing, China. BSc. Biology

2.1999-2002: Capital Normal University, Beijing, China. MSc. Bioengineering

3.2002-2005:The Chinese Academy of Medical Sciences (CAMS) &The Peking Union Medical College (PUMC), Beijing, China. PhD. Microbiology and Biochemical Pharmacy

4.2005-2010: Johns Hopkins University, MD, USA PostdocFellow. Infectious Diseases Supervised mainly by Prof. Jacques H. Grosset andProf. Eric L. Nuermberger. He learned from Prof. William Bishai’s Lab,too.

1. 2018-Present: Director of Tuberculosis Lab of State KeyLaboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine andHealth (GIBH), Chinese Academy of Sciences (CAS) and Director of the Pathogenic Bacteria Research Laboratory.

2. 2018: The outstanding award of the fifth GuangdongPatent Award.

3. 2017-Present: The 9th Executive director of Guangdong Anti-tuberculosis Association

4.2017-Present: Member of European Respiratory Society.

5.2017-Present: “Scientific and Technological InnovationLeading Talent” of 2016Guangdong Special Support Plan.

6.2015-Present: Editor of Frontiers inMedicine,FrontiersinPublicHealthand FrontiersinMicrobiology.

7.2013- Present: Member of Institutional Animal Care and UseCommittee (IACUC), Guangzhou Institutes of Biomedicine and Health (GIBH),Chinese Academy of Sciences.

 8.2012-Present: Co-director of Tuberculosis Lab of State KeyLaboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine andHealth (GIBH), Chinese Academy of Sciences (CAS). 

9.2012: ‘One Hundred Talent’ of the Chinese Academyof Sciences.

10.2011-Present: Professor, State Key Laboratory ofRespiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH),Chinese Academy of Sciences (CAS).

11.2011-Present: Professor, Faculty of Medical Biotechnology(joint faculty of GIHB and USTC), School of Life Sciences, University ofScience and Technology of China (USTC). 

12.2011-Present: Member of American Thoracic Society. 

13.2011-Present: Member of American Society for Microbiology.

14.2010-Present: Professor, Leader of Tuberculosis Lab,Center for Infection and Immunity, Guangzhou Institutes of Biomedicine andHealth (GIBH), Chinese Academy of Sciences (CAS). 

15.2005-2010: Post-doctoral fellow, Johns HopkinsUniversity.

Research Fields

        1. Postgenomics of Mycobacterium tuberculosis;

        2. Research & development of anti-tuberculosis drugs and diagnostic tools and the study of mechanism of the drug action and drug resistance;

3. Immunology and the research & development of vaccine of tuberculosis;

4. Interaction between bacteria and host, development of vaccine;

5. Synthetic biology.